In the context of birth defects, which of the following is true of sickle-cell anemia?
A. It is a metabolic disorder resulting in mental retardation.
B. Families of Mediterranean descent are primarily at risk for sickle-cell anemia.
C. It increases susceptibility of at-risk individuals to pneumonia and stroke.
D. Treatment for sickle-cell anemia involves regular blood transfusions with clotting factors.
Answer: C
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