Consider the observations that a label on one head of a myosin V dimer moves in steps of 72 nm, but a label much nearer the myosin tail moves in steps of 36 nm

Discuss how these observations support a hand-over-hand mechanism rather than an inchworm mechanism of myosin V motility on an actin filament.
What will be an ideal response?


Answer: In the inchworm model, each myosin head would move in steps of 36 nm, as the trailing head moves 36 nm up to the position just behind the leading head and the leading head then steps forward 36 nm. In the hand-over-hand model, the trailing head steps a total of 76 nm as it pivots past the leading head to become the new leading head, whereas the tail region moves only 36 nm forward (see Fig. 14A-2).

Biology & Microbiology

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