Explain how these two checkpoints correlate with the process of allelic exclusion that ensures that only one heavy-chain locus and one light-chain locus produce functional gene products
What will be an ideal response?
Checkpoint 1 delivers an important signal to the cell, verifying that a functional heavy chain has been made. This triggers the cessation of heavy-chain gene rearrangement followed by the inactivation of surrogate light-chain synthesis. Thus, only one heavy-chain locus ends up producing a product. As surrogate light chain becomes unavailable, μ accumulates and is retained in the endoplasmic reticulum, ready to bind to functional light chain when that is synthesized after successful light-chain gene rearrangement. Checkpoint 2 signals the cessation of light-chain rearrangement. This ensures that only one light-chain locus out of the possible four produces a functional product.
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