A genetics specialist tells a family that their child's disorder occurred due to uniparental disomy. The nurse would consider which information before explaining this information to the parents?
Note: Credit will be given only if all correct choices and no incorrect choices are selected.
Standard Text: Select all that apply.
1. The disorder is Mendelian dominant.
2. One of the parents carries the gene for the condition.
3. Both parents carry a gene for the disorder.
4. The child received two alleles from the same parent.
5. Uniparental disomy is also known as imprinting.
2,4
Rationale 1: Uniparental disomy results in Mendelian recessive disorders.
Rationale 2: Only one of the parents carries the gene in uniparental disomy.
Rationale 3: If both parents carry a gene, Mendelian inheritance occurs. Uniparental disomy does not follow expected Mendelian inheritance patterns.
Rationale 4: In uniparental disomy, both alleles responsible for the expression of the disorder are contributed by the same parent.
Rationale 5: Unlike uniparental disomy, imprinting occurs when there is an unequal expression of each allele.
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