A client with a diagnosis of peptic ulcer disease is prescribed omeprazole (Prilosec) and asks the nurse where in the body this medication will work. The nurse correctly answers:

Question

1. "On the gastric mucus layer."
2. "On the mucosa of the trachea."
3. "On the surface of parietal cells."
4. "On the H2 receptors."

Answer 1

Correct Answer: 3
Rationale 1: Omeprazole is a proton pump inhibitor and works on the proton pump, which is located on the surface of parietal cells.
Rationale 2: Omeprazole is a proton pump inhibitor and works on the proton pump, which is located on the surface of parietal cells.
Rationale 3: Omeprazole is a proton pump inhibitor and works on the proton pump, which is located on the surface of parietal cells.
Rationale 4: H2-receptor antagonists work on H2 blockers. Omeprazole is a proton pump inhibitor and works on the proton pump, which is located on the surface of parietal cells.
Global Rationale: PPIs, such as omeprazole, reduce acid secretion in the stomach by binding irreversibly to the H?, K?-ATPase enzyme at the surface of the parietal cell, thereby blocking the final step in acid production. It does not work on the gastric mucosa layer or in the trachea. H2-receptor antagonists work on H2 blockers.