A patient diagnosed with depression has been taking a selective serotonin-reuptake inhibitor (SSRI) throughout her pregnancy. What neonatal consequences are possible?
1. Malformations
2. High birth weight
3. Neural tube defects
4. Poorer neurobehavioral adaptation
Answer: 4
Explanation: Poorer neurobehavioral adaptation (PNA), similar to the discontinuation symptoms of SSRIs, has been shown in neonates whose mothers were taking SSRIs. There is no association between malformations and SSRI use in pregnancy. Low birth weight may be an adverse outcome of maternal SSRI use. Neural tube defects have been associated with certain mood stabilizers.
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