Why are statins, or HMG CoA reductase inhibitors, administered at bedtime?
a. The stomach is empty.
b. Metabolic needs of the body are decreased.
c. Cholesterol production is at its peak.
d. The body temperature is increased.
ANS: C
The peak production of cholesterol is during the night. Therefore, HMG CoA reductase inhibitors are more effective when administered at bedtime. Statins should be taken with food, not on an empty stomach. Metabolic needs of the body and body temperature do not affect the administration of statins.
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