The presence of spherocytes in blood can:
a. Elevate the mean cell volume (MCV)
b. Elevate the erythrocyte sedimentation rate (ESR)
c. Elevate the mean cell hemoglobin concentration (MCHC)
d. Elevate the WBC count.
ANS: C
Spherocytes can slightly elevate the MCHC because they have lost some membrane in the process of sphering and so the hemoglobin concentration tends to increase slightly. The MCV is usually not significantly affected (although microspherocytes exist). Spherocytes decrease the ESR and have no effect on the white count.
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