A 21-year-old woman has a primary complaint of menorrhagia. Her coagulation screen gives the following results. What disorder is most likely?
Test Result Reference range
Prothrombin time (PT) 12.0 seconds 11-15 seconds
Partial thromboplastin time (PTT) 40 seconds 25-37 seconds
Factor VIII activity 35% 50%-150%
Platelet count 225 x 109/L 150-400 x 109/L
a. Hemophilia A
b. Hemophilia B
c. VWD, type 1
d. Factor X deficiency
ANS: C
VWD is the most prevalent of the congenital bleeding disorders, affecting both female and male subjects; hemophilia A and B both affect primarily male subjects. Female patients with VWD often complain of menorrhagia. Most patients with VWD have factor VIII levels in the range of 35% to 50%.
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