The primary reason for evaluating alpha-fetoprotein (AFP) levels in maternal serum is to determine if the fetus has
a. Hemophilia
b. A neural tube defect
c. Sickle cell anemia
d. A normal lecithin/sphingomyelin (L/S) ratio
B
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A Hemophilia is a genetic defect and is best detected with chromosomal studies
such as chorionic villus sampling or amniocentesis.
B An open neural tube allows a high level of AFP to seep into the amniotic fluid
and enter the maternal serum.
C Sickle cell is a genetic defect and is best detected with chromosomal studies such
as chorionic villus sampling or amniocentesis.
D L/S ratios are determined with an amniocentesis and is usually done in the third
trimester.
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