Describe/summarize the four major stages of catabolism


• Stage 1: complex molecules are broken down into their fundamental building blocks.
glycogenolysis – glycogen ? glucose
proteolysis – protein ? amino acids
lipolysis – triglycerides ? fatty acids and glycerol molecules
• Stage 2: glucose, amino acids, fatty acids, and glycerol enter specific pathways in which each is converted into an intermediate product that can enter the citric acid cycle.
• Stage 3: intermediate products formed during Stage 2 enter the citric acid cycle and are broken down further to form carbon dioxide, releasing energy in the process. Much of the energy released during Stage 3 of metabolism is transferred to the coenzymes NAD+ and FAD, forming NADH + H+ and FADH2, respectively. In addition, small amounts of ATP are formed via substrate phosphorylation.
• Stage 4: begins when NADH + H+ and FADH2 enter the electron transport chain. The energy-yielding pathways of oxidative phosphorylation operate in nearly all cells to produce energy for cellular activities.

Nutritional Science

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