A patient has been prescribed mirtazapine (Remeron). How will it decrease migraine headaches and depression?
A) It increases concentration of endogenous epinephrine.
B) It blocks the presynaptic alpha2-adrenergic receptors.
C) It acts on the dopamine only receptors in the brain.
D) It inhibits norepinephrine and serotonin reuptake.
B
Feedback:
Mirtazapine blocks presynaptic alpha2-adrenergic receptors (which increase the release of norepinephrine), serotonin receptors, and histamine H1 receptors. Consequently, the drug decreases anxiety, agitation, insomnia, and migraine headaches as well as depression.
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