A 25-year-old male is in a car accident and sustains a fracture to his left femur with extensive soft tissue injury. The pain associated with the injury is related to:
a. histamine.
b. prostaglandins.
c. vasoconstriction.
d. immune complex formation.
ANS: B
Prostaglandins cause increased vascular permeability, neutrophil chemotaxis, and pain by direct effects on nerves. Histamine promotes vasodilation. Prostaglandins are not associated with vas-oconstriction or the immune complex formation.
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