A patient requires a high dose of his new antihypertensive medication because the new medication has a significant first-pass effect. This means that the drug
A) must pass through the patient's bloodstream several times to generate a therapeutic effect.
B) passes through the renal tubules and is excreted in large amounts.
C) is extensively metabolized in the patient's liver.
D) is ineffective following the first dose and increasingly effective with each subsequent dose.
C
Feedback:
Some drugs are extensively metabolized in the liver, with only part of a drug dose reaching the systemic circulation for distribution to sites of action. This is called the first-pass effect or presystemic metabolism. The first-pass effect is not related to renal function or the need to pass through the bloodstream multiple times.
You might also like to view...
The administration of a health care organization has proposed a new client care area staffing system
Which components of this system do not meet the American Nurses Association (ANA) requirements? Note: Credit will be given only if all correct choices and no incorrect choices are selected. Standard Text: Select all that apply. 1. Registered nurses from across the facility were included on the committee that developed the system. 2. RNs will be required to accept flexible schedules that might require the nurse to practice on any unit in the facility. 3. The nurse's level of educational preparation will be considered in staffing decisions. 4. The number of clients and their acuity will be considered for staffing purposes. 5. When low census occurs the unlicensed assistant category will be first to be furloughed.
During a health history, the nurse asks a male patient about alcohol use. The patient tells the nurse that he and his wife are trying to conceive a pregnancy and he is using alcohol to lower his inhibitions
What will the nurse counsel this patient? a. "Alcohol causes increased masculiniza-tion." b. "Alcohol may cause testicular atrophy and sterility." c. "Alcohol will improve your chances of conceiving." d. "Alcohol will also help you to ejaculate."
A child with hemophilia requires frequent emergency infusions of antihemophilic factor replacement therapy (AHF)
The mother becomes distraught during one infusion and starts crying, saying "It's all my fault my child has to suffer so!" An appropriate intervention by the nurse would be to a. call the social worker to come sit with the mother during the infusion. b. explain to the mother that it was the father who gave the child hemophilia. c. gently remind the mother that she cannot control genetics. d. offer resources to teach the mother home AHF infusion technique.
An adolescent is
A. 12 to 14 years of age. B. 12 to 16 years of age. C. 16 to 18 years of age. D. 14 to 20 years of age.