What is the concern if Pelger-Huët anomaly is not recognized?
a. Without treatment, the patient will probably die.
b. The cells could be misclassified as immature neutrophils, indicating that the patient has a bacterial infection when he or she does not.
c. The patient could develop pseudo–Pelger-Huët followed by leukemia.
d. The cells could be misclassified as blasts, indicating that the patient has acute leukemia when he or she does not.
ANS: B
Pelger-Huët cells, because they often have bilobed nuclei, may be mistaken for band neutrophils or metamyelocytes. Those with a round nucleus may be mistakenly reported as myelocytes. This left shift is characteristic of a bacterial infection.
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