A patient diagnosed with intermittent claudication will be discharged to home on cilostazol (Pletal). Which of the following statements made by the patient indicates a need for further dis-charge instruction?
a. "I will take the cilostazol with grapefruit juice."
b. "Headache may be a side effect of the cilostazol."
c. "I will take the cilostazol 30 minutes before breakfast and 30 minutes before din-ner."
d. "I should expect less pain and cramping in my legs when walking."
A
Cilostazol levels can be increased by grapefruit juice.
Headache is the most common adverse effect of cilostazol (34%).
The usual dosage of cilostazol is 100 mg twice daily, taken 30 minutes before or 2 hours after breakfast and the evening meal.
Because cilostazol promotes vasodilation by inhibiting PDE3 in blood vessels, the patient will have less pain and cramping during activity.
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