Two nurses are contrasting the major differences between physostigmine (Antilirium) and neostigmine (Prostigmin). One nurse correctly states that physostigmine (Antilirium)
a. is not as effective for treating poisoning by muscarinic-blocking drugs.
b. can readily cross the blood-brain barrier.
c. does not cause any side effects.
d. cannot reverse the effects of neuromuscular blockers.
B
The basic pharmacology of physostigmine is nearly identical to that of neostigmine, the exception being that physostigmine readily crosses membranes, including the blood-brain barrier. Neostigmine does not.
Physostigmine and neostigmine are both effective for treating poisoning by muscarinic blocking drugs.
Neither physostigmine nor neostigmine is devoid of side effects.
Physostigmine cannot reverse the effects of neuromuscular blockers.
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