If you were given a new necklace and developed reddening, swelling, and itching of your skin around your neck 24 hours after putting on the necklace, what reason would you give to this phenomenon? What immune cells are involved?
What will be an ideal response?
Answer: This is a case of delayed-type hypersensitivity (DTH) or type IV hypersensitivity. Chemical constituents of the jewelry are covalently binding to your skin proteins and creating new antigens to elicit a DTH response known as contact dermatitis. The immune cells involved are the TH cells. These cells produce an inflammatory response that causes localized tissue damage, pain, blistering, and itching.
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