The nurse educator is planning to teach a group of pharmacology students about enterohepatic recirculation. What should the educator include in the presentation?
1. Enterohepatic recirculation involves the kidneys.
2. Enterohepatic recirculation results in prolonged drug action.
3. Enterohepatic recirculation results in a decreased drug action.
4. Enterohepatic recirculation does not affect drug action.
Correct Answer: 2
Rationale 1: Involves the kidneys is incorrect because enterohepatic recirculation involves the liver.
Rationale 2: Elimination of drugs through bile can continue for several weeks after therapy has stopped, and results in prolonged drug action.
Rationale 3: Results in decreased drug action is incorrect because recirculating drugs are then metabolized by the liver and excreted by the kidneys. The fraction of drug that is not recirculated continues on its way to the feces. Elimination of drugs through bile can continue for several weeks after therapy has stopped, and results in prolonged drug action.
Rationale 4: Does not affect drug action is incorrect because recirculating drugs are then metabolized by the liver and excreted by the kidneys. The fraction of drug that is not recirculated continues on its way to the feces. Elimination of drugs through bile can continue for several weeks after therapy has stopped, and results in prolonged drug action.
Global Rationale: Elimination of drugs through bile can continue for several weeks after therapy has stopped, and results in prolonged drug action. Involves the kidneys is incorrect because enterohepatic recirculation involves the liver. Results in decreased drug action is incorrect because recirculating drugs are then metabolized by the liver and excreted by the kidneys. The fraction of drug that is not recirculated continues on its way to the feces. Elimination of drugs through bile can continue for several weeks after therapy has stopped, and results in prolonged drug action. Does not affect drug action is incorrect because recirculating drugs are then metabolized by the liver and excreted by the kidneys. The fraction of drug that is not recirculated continues on its way to the feces. Elimination of drugs through bile can continue for several weeks after therapy has stopped, and results in prolonged drug action.
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