Explain the negative feedback loop by which erythropoiesis is regulated

What will be an ideal response?


The negative feedback loop that maintains erythropoiesis primarily involves the hormone erythropoietin (EPO), with the concentration of oxygen in the blood influencing the production of this hormone. When blood oxygen levels fall below normal, kidney cells detect the falling oxygen levels. The kidneys produce more EPO and release it into the blood. Erythrocyte production in the red bone marrow increases and homeostasis is restored when blood oxygen levels return to normal.

Anatomy & Physiology

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Anatomy & Physiology