What is the maximum Lod score for this mating?

A) 0.22
B) 1.1
C) 6.3
D) 11


A) 0.22


Explanation: 3 individuals out of 9 total are recombinant.

The denominator of the Lod score calculation is (1/2)9 = 1.95 × 10-3

The numerator of the Lod score uses the formula (1 - RFobs)#P × (RFobs)#R. Here, RFobs = 3/9, #P = 6, and #R = 3. Thus the numerator is (6/9)6 × (3/9)3 = 3.25 × 10-3

The likelihood ratio is 3.25 × 10-3 / 1.95 × 10-3 = 1.667

The Lod score is log10(1.667) = 0.22

Biology & Microbiology

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