A patient who has elevated thyroxine production should be assessed for which accompanying condition?
a. Increased thyroid-releasing hormone (TRH)
b. Increased anterior pituitary stimulation
c. Decreased T4
d. Decreased thyroid-stimulating hormone (TSH)
ANS: D
Secretion of TSH stimulates the synthesis and secretion of thyroid hormones. Increasing levels of T4 and T3 then feedback negatively on the pituitary and hypothalamus to inhibit TRH and TSH synthesis. With increased thyroxine production, TRH will be decreased. Increased thyroxine would lead to decreased anterior pituitary stimulation. Thyroxine is T4; its level will be elevated.
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