What is the primary factor that maintains the pressure gradient that drives O2 from the capillaries into the interstitial spaces and into the cells?
a. Bohr effect on the RBC
b. Cellular consumption of O2
c. Haldane effect on the RBC
d. Increased carbon dioxide in blood de-creasing Hb affinity for O2
ANS: B
As cellular metabolism depletes its O2, the intracellular PO2 drops below that of the blood enter-ing the tissue capillary. This provides the diffusion gradient by which O2 diffuses from the tissue capillary blood (PO2 = 100 mm Hg) to the cells (PO2 < 40 mm Hg).
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