Diepoxybutane causes chromosomal breakage in which of the following disorders?
a. Acquired aplastic anemia
b. Fanconi anemia
c. Diamond-Blackfan anemia
d. CDA
ANS: B
Diepoxybutane is a deoxyribonucleic acid (DNA) cross-linking agent. When this is added to Fanconi anemia cells in culture, a characteristic chromosomal breakage occurs. This is the diagnostic test for Fanconi anemia.
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