Why are adrenergic agonists such as epinephrine given parenterally or by inhalation instead of orally?
1. They are not easily digested in the gastrointestinal tract.
2. They produce toxic by-products in the blood.
3. They are rapidly absorbed by the blood.
4. They are metabolized by the enzyme COMT in the intestinal tract.
Correct Answer: 4
Rationale 1: Adrenergic agonists are not digested in the gastrointestinal tract.
Rationale 2: No toxic by-products are produced.
Rationale 3: Adrenergic agonists are not rapidly absorbed by the blood.
Rationale 4: Epinephrine is metabolized by the enzymes MAO and COMT in the liver and in most tissues; hence, it is not absorbed orally.
Global Rationale: Epinephrine is metabolized by the enzymes MAO and COMT in the liver and in most tissues; hence, it is not absorbed orally. Adrenergic agonists are not digested in the gastrointestinal tract. No toxic by-products are produced. Adrenergic agonists are not rapidly absorbed by the blood.
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