Which of the following is true regarding the mechanism of warm-reactive autoimmune hemolytic anemia?
a. Immunoglobulin G (IgG) autoantibodies cause intravascular hemolysis.
b. IgG autoantibodies cause extravascular hemolysis.
c. Immunoglobulin M (IgM) alloantibodies cause complement activation.
d. IgM autoantibodies cause immune complex formation.
ANS: B
Cold-reactive autoimmune hemolytic anemia caused is sometimes secondary 2 – 3 weeks after infections such as M. pneumoniae and infectious mononucleosis.
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