Which of the following statements are true of a T cell that expresses two ? chains (and thus two different T-cell receptors) as a result of ineffective allelic exclusion of the ? chain during rearrangement? (Select all that apply.)
a. Engaging either of the T-cell receptors on MHC molecules of the thymic epithelium will result in positive selection.
b. One of the T-cell receptors will be functional while the other will most probably be non-functional.
c. If either T-cell receptor binds strongly to self-peptides presented by self-MHC molecules, the thymocyte will be negatively selected.
d. One of the T-cell receptors may be autoreactive but escape negative selection because its peptide antigen is present in tissues other than the thymus.
e. Subsequent gene rearrangements may give rise to a ?:? T-cell receptor.
a, b, c, d
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