Which statement regarding medication distribution within the body is accurate?
1. The blood–brain barrier inhibits rapid crossing of all medications.
2. Body organs with high levels of blood flow are more difficult organs to which to deliver drugs.
3. Medications that are lipid-soluble are more completely distributed.
4. Drug–protein complexes must form prior to crossing capillary membranes.
Correct Answer: 3
Rationale: Lipid-soluble medications are absorbed and distributed quicker and more quickly than those that are not. Body organs with low levels of blood flow are more difficult organs to which to deliver drugs. When medications bind to proteins, their size increases, preventing them from passing through capillary membranes. Some medications (sedatives) are able to rapidly cross the blood–brain barrier. (pp. 39–40)
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