Why do children who have had their tonsils or adenoids removed respond less effectively to the oral polio vaccine than children who still have these tissues?
What will be an ideal response?
Tonsils and adenoids are located in the oral cavity and are composed of extensive secondary lymphoid tissue making up Waldeyer's ring. They are responsible for the production of secretory IgA specific for infectious material entering the gut and airways. The oral polio vaccine elicits the most effect protective immunity through the production of secretory IgA, including the secondary lymphoid tissues of Waldeyer's ring.
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