You are reviewing the data from several meta-analyses that addressed the most common causes of adverse drug reactions in the older adult. Which of the following would you find to be decreased and the most common cause of these problems in older adults?
1. Body fat content
2. Liver function
3. Renal function/clearance
4. Plasma albumin levels
ANS: 3
RAT: Renal function declines with age, causing drug elimination to be slowed in older adults. Older adults have increased body fat. Liver dysfunction and hypoalbuminemia are not normal age-related changes but can be seen in association with disease states.
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