Aspirin is ionized as it enters the small intestine. Which statement is accurate regarding the absorption of aspirin in the small intestine?
1. Absorption is decreased.
2. Absorption is increased.
3. Ionization has nothing to do with the absorption rate.
4. Aspirin must travel past the small intestine for absorption to occur.
Correct Answer: 1
Rationale: The small intestine is a more alkaline environment, which facilitates the absorption of basic drugs. Aspirin is an acidic drug that is ionized in the small intestine, and will have lower absorption rates. Higher rates of absorption occur in the stomach (an acidic environment).
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