In 1937, two German biochemists published a paper proposing the following reactions as part of the glucose oxidation. citrate isocitrate -ketoglutarate succinate fumarate malate oxaloacetate
Adding succinate, fumarate, or malate to thin slices of tissue increased oxygen consumption,
supporting the hypothesis that these molecules are intermediates in the process. However, a
puzzling observation was that intermediates were still present in the reaction mixture at the
end of the experiment. If they are intermediates, then they should be consumed as the next
product in the pathway is formed. What explains this observation?
A. Succinate, fumarate, and malate are not
reactants but catalysts, and catalysts are not
consumed in the process.
B. Succinate, fumarate, and malate are
constantly regenerated in the citric acid
pathway.
C. Succinate, fumarate, and malate increase
metabolism and therefore oxygen
consumption, but they are not directly part of
the glucose oxidation pathway.
B
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Fill in the blank(s) with the appropriate word(s).
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a. true b. false
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