What reactions to medications are influenced by chemical biotransformations in the liver's enzymatic pathways? Select all that apply
1. Tolerance
2. Toxicity
3. Potency
4. Resistance
5. Therapeutic range
Answer: 1, 2, 4
Explanation: An enzyme system in the liver facilitates chemical biotransformations. Reactions in these enzymatic pathways contribute to drug resistance, drug tolerance, and drug toxicity. The amount (dose) of the drug necessary to produce the desired response is its potency. The therapeutic range is the range at which therapeutic efficacy can be achieved without risking harm to the patient.
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