In the mature central nervous system (CNS), axonal regeneration is impeded by which of the following?
A. Glial scar formation
B. Absence of neural growth factor
C. Release of growth inhibiting factors
D. Both A and B
E. A, B, and C
ANS: E
Rationale: Development of glial scars, limited expression or complete absence of nerve growth factor (NGF), and growth inhibiting factors prevent functional axonal regeneration in the brain and spinal cord.
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