Malignant hyperthermia is a hereditary disorder that can increase surgical risk, due to elevated temperature during certain types of anesthesia

The cause of the increased temperature is an increased cytosolic Ca++ level secondary to an anesthetic-induced:

A. increased Ca++ release from the SR, due to a mutation in the ryanodine receptor
B. decreased Ca++ uptake by the SR, due to a mutation in SERCA
C. increased frequency of rupturing of skeletal muscle fibers
D. decreased Ca++ extrusion, due to hyperphosphorylation of the plasmalemmal Ca++ pump
E. increased Ca++ influx, due to a mutation in N-type Ca++ channels


ANS: A

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