Common to both the intrinsic and the extrinsic pathway is:
a. factor XII
b. factor VII.
c. factor X.
d. subendothelial collagen.
C
When blood is exposed to subendothelial collagen or is "injured," factor XII is activated, which initiates coagulation via the intrinsic pathway. In the extrinsic pathway, tissue injury precipitates release of a substance known as tissue factor, which activates factor VII. Factor VII is key in initiating blood coagulation, and the two pathways intersect at the activation of factor X. Both coagulation pathways illustrate a final common pathway of clot formation, retraction, and fibrinolysis.
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