Which of the following best explains why a bone marrow donor needs to be HLA-matched to the recipient?
a. The bone marrow transplant contains enough mature T cells to reconstitute the recipient and the recipient provides the antigen-presenting cells.
b. The recipient's MHC molecules mediate positive selection of thymocytes in the thymus that interact with donor-derived MHC molecules in the periphery.
c. Reconstituted T cells are restricted by donor, not recipient, HLA allotypes.
d. Without an HLA match, the donor-derived thymocytes undergo negative selection.
e. If the donor is not HLA matched, the reconstituted T cells will be autoreactive.
b
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