The health care provider has prescribed penicillin and probenecid for a patient with a sexually transmitted disease. What is the purpose of combining these medications?
a. To accelerate the excretion of the penicillin
b. To inhibit the absorption of penicillin to allow the drug to remain in the transport phase
c. To inhibit the excretion of the penicillin
d. To reduce toxic effects associated with penicillin
ANS: C
The combination therapy of penicillin and probenecid allows the penicillin to remain in the body longer, which enhances drug availability and action. The combination may be used advantageously in treating serious or resistant infections. Probenecid inhibits the excretion of penicillin, slows down the excretion of penicillin, and does not affect absorption or toxic effects.
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