The nurse evaluates a client taking a high daily dose of duloxetine (Cymbalta) for which signs and symptoms?(Select all that apply.)
1. Suicidal ideation
2. Increased libido
3. Liver failure
4. Seizures
5. Hypotension
1, 3, 4
Rationale 1: Suicidal ideation is possible because duloxetine (Cymbalta) can cause suicidal ideation.
Rationale 2:Duloxetine (Cymbalta) causes sexual dysfunction.
Rationale 3: Liver failure is possible because duloxetine (Cymbalta) causes liver toxicity at high doses.
Rationale 4: Seizures are possible because duloxetine (Cymbalta) lowers seizure threshold at high doses.
Rationale 5: Hypotension is not likely with a high dose of duloxetine (Cymbalta).
Global Rationale: Suicidal ideation is possible because duloxetine (Cymbalta) can cause suicidal ideation. Duloxetine (Cymbalta) causes sexual dysfunction. Liver failure is possible because duloxetine (Cymbalta) causes liver toxicity at high doses. Seizures are possible because duloxetine (Cymbalta) lowers seizure threshold at high doses. Hypotension is not likely with a high dose of duloxetine (Cymbalta).
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