A pregnant woman asks the nurse about whether a medication is safe to take during pregnancy. The nurse notes that the drug has a low molecular weight. Based on this drug characteristic, the nurse understands that this drug
a. can cause greater gastrointestinal distress and hyperemesis.
b. has reduced renal elimination resulting in toxicity.
c. is more sensitive to metabolism by circulating maternal hormones.
d. will be more likely to cross the placenta and affect the fetus.
ANS: D
Low-molecular weight drugs are more likely to cross the placental barrier. This characteristic does not contribute to increased GI distress or toxicity because of reduced renal elimination. Drugs with low molecular weight are not more sensitive to metabolism by maternal hormones.
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