A client has been prescribed nilotinib (Tasigna) for treatment of chronic myeloid leukemia. The nurse should give the client which instructions?
1. "Take this medication in the morning, on an empty stomach, with a glass of citrus juice such as orange juice or grapefruit juice."
2. "You will also be prescribed the antibiotic ciprofloxin, as nilotinib increases your risk for developing respiratory infections."
3. "You should return to the clinic in 7 days for an ECG."
4. "You can take this drug without concern as to whether or what you have eaten."
3
Rationale 1: This drug should not be taken with grapefruit juice.
Rationale 2: Nilotinib should not be taken concurrently with ciproloxin.
Rationale 3: Nilotinib may cause QT prolongation. The client should have a baseline ECG, an ECG in 7 days, and then periodically throughout treatment.
Rationale 4: The client should take this drug on an empty stomach and should avoid grapefruit.
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