The nurse is caring for a client who is receiving medications from several different classifications for the treatment of multiple health problems
For which medications or classifications does the nurse anticipate prolonged activity due to enterohepatic recirculation?
1. Mebendazole (Vermox)
2. Digoxin (Lanoxin)
3. Phenothiazines
4. Topical steroids
5. Topical anti-infectives
Correct Answer: 2,3
Rationale 1: Certain oral drugs travel through the GI tract without being absorbed and are excreted in the feces. Mebendazole (Vermox), a drug used to kill intestinal worms, is such a drug.
Rationale 2: Some drugs may be recirculated numerous times with the bile, thus extending their stay in the body; biliary excretion is influential in prolonging the activity of digoxin (Lanoxin).
Rationale 3: Some drugs may be recirculated numerous times with the bile, thus extending their stay in the body; biliary excretion is influential in prolonging the activity of phenothiazines.
Rationale 4: Topical steroids are not subject to enterohepatic recirculation.
Rationale 5: Topical anti-infectives are not subject to enterohepatic recirculation.
Global Rationale: Some drugs may be recirculated numerous times with the bile, thus extending their stay in the body; biliary excretion is influential in prolonging the activity of digoxin (Lanoxin) and phenothiazines. Certain oral drugs travel through the GI tract without being absorbed and are excreted in the feces. Mebendazole (Vermox), a drug used to kill intestinal worms, is such a drug. Topical steroids are not subject to enterohepatic recirculation. Topical anti-infectives are not subject to enterohepatic recirculation.
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