Which of the following would be considered a major cause of secondary hyperlipoproteinemia since it increases the production of VLDL and conversion to LDL?
A) High-calorie diet
B) Diabetes mellitus
C) Bile-binding resin
D) Cholesterol ingestion
Ans: A
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Obesity with high-calorie intake increases the production of VLDL, with triglyceride elevation and high conversion of VLDL to LDL. Excessive cholesterol intake reduces formation of LDL receptors. Diabetes is associated with high triglycerides and minimal elevation of LDL. Bile salt–binding resin is one treatment used to lower cholesterol levels.
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