After genetic testing, a client is suspected of having mitochondrial gene alteration. When reviewing the test result with the client, which body systems are noted as being affected by this alteration? Select all that apply

1. Brain
2. Renal
3. Cardiac
4. Genitourinary
5. Musculoskeletal


1, 3, 5
Explanation:
1. Clinical manifestations occurring as a result of mitochondrial gene alterations primarily affect high-energy tissues such as the brain.
2. Clinical manifestations occurring as a result of mitochondrial gene alterations primarily affect high-energy tissues. The renal system is not identified as being affected.
3. Clinical manifestations occurring as a result of mitochondrial gene alterations primarily affect high-energy tissues such as cardiac muscle.
4. Clinical manifestations occurring as a result of mitochondrial gene alterations primarily affect high-energy tissues. The genitourinary system is not identified as being affected.
5. Clinical manifestations occurring as a result of mitochondrial gene alterations primarily affect high-energy tissues such as skeletal muscle.

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