What coagulation screening test is the most sensitive for detecting mild liver disease?
a. Fibrinogen
b. PTT
c. PT
d. TT
ANS: C
Liver disease particularly affects production of the vitamin K–dependent proteins. Because the PT is sensitive to factor VII activity and it (factor VII) has a short half-life of 3 to 5 hours, the PT is the most sensitive for detecting mild liver disease.
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