A patient is preparing to travel to a country with prevalent malaria. To prevent contracting the disease, the provider has ordered chloroquine HCl (Aralen). The nurse will instruct the patient to take this drug according to which schedule?
a. 500 mg weekly beginning 2 weeks prior to travel and continuing for 6 to 8 weeks after travel
b. 1000 mg weekly beginning 2 weeks prior to travel and continuing for 6 to 8 weeks after travel
c. 500 mg once followed by 500 mg per dose in 6 hours, 24 hours, and 48 hours
d. 1000 mg once followed by 500 mg per dose in 6 hours, 24 hours, and 48 hours
ANS: A
For malaria prophylaxis, chloroquine is given 500 mg/dose weekly for 2 weeks prior to travel and then weekly until 6 to 8 weeks after exposure. The dosing schedule of 1000 mg once, followed by 500 mg in 6, 24, and 48 hours is used to treat acute malaria.
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