What is a biological condition that occurs when the body adapts to a substance after it is repeatedly administered, and a higher dose is needed to achieve the initial response?

1. Tolerance
2. Dependence
3. Addiction
4. Cross-tolerance


Correct Answer: 1

Rationale 1: Tolerance is a biological condition that occurs when the body adapts to a substance after it is repeatedly administered, and a higher dose is needed to achieve the initial response.
Rationale 2: Dependence is incorrect because dependence occurs when a person has an overwhelming desire to take a drug and cannot stop.
Rationale 3: Addiction is incorrect because addiction is the progressive and chronic abuse of a substance caused by an overwhelming feeling that drives someone to use a drug repeatedly despite serious consequences.
Rationale 4: Cross-tolerance is incorrect because once tolerance develops to one substance, it often also occurs with use of closely related drugs.

Global Rationale: Tolerance is a biological condition that occurs when the body adapts to a substance after it is repeatedly administered, and a higher dose is needed to achieve the initial response. Dependence is incorrect because dependence occurs when a person has an overwhelming desire to take a drug and cannot stop. Addiction is incorrect because addiction is the progressive and chronic abuse of substance caused by an overwhelming feeling that drives someone to use a drug repeatedly despite serious consequences. Cross-tolerance is incorrect because once tolerance develops to one substance, it often also occurs with use of closely related drugs.

Nursing

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