A client is prescribed aripiprazole (Abilify) to treat both the positive and negative symptoms of schizophrenia. What will the nurse explain as the medication's mechanism of action?
1. Increasing norepinephrine activity by blocking its synaptic reuptake
2. Partial agonist activity at dopamine type 2 (D2 and D3) and serotonin type 2
3. Inhibiting the reuptake of serotonin at the synapse
4. Binding to the GABA receptor
Correct Answer: 2
Rationale 1: Antipsychotics do not increase norepinephrine activity.
Rationale 2: By blocking D2 receptors, antipsychotic drugs reduce the symptoms of schizophrenia.
Rationale 3: Antipsychotics do not inhibit the reuptake of serotonin.
Rationale 4: Antipsychotics do not bind to the GABA receptor.
Global Rationale: By blocking D2 receptors, antipsychotic drugs reduce the symptoms of schizophrenia. Antipsychotics do not increase norepinephrine activity, inhibit the reuptake of serotonin, or bind to the GABA receptor.
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