A patient who has been diagnosed with human immune deficiency syndrome is given ganciclovir (Cytovene) to prevent cytomegalovirus. The patient develops granulocytopenia
How long will it take for the granulocytes to regenerate after the ganciclovir is discontinued? A) 5 days
B) 7 days
C) 10 days
D) 14 days
B
Feedback:
Ganciclovir causes granulocytopenia and thrombocytopenia in 20% to 40% of recipients, often during the first 2 weeks of therapy. If severe bone marrow depression occurs, ganciclovir should be discontinued; recovery usually occurs within a week of stopping the drug. Five days after discontinuing the drug is too soon to see a change in granulocytopenia. Ten to fourteen days is too long for change to occur. It should have occurred within 1 week.
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