A client on long-term therapy with itraconazole (Sporanox) for treatment of a nail fungus is admitted to the hospital with right upper quadrant pain, nausea, and abdominal pain
Which laboratory results found in the medical record would support the diagnosis of hepatotoxicity?
1. Elevated liver function tests
2. Elevated creatinine levels
3. Decreased blood sugar
4. Decreased prothrombin time
Correct Answer: 1
Rationale 1: Elevated liver function tests, which include the enzymes ALT and AST, are indicative of liver inflammation and/or impaired function of the liver.
Rationale 2: Elevated creatinine levels are indicative of impaired renal function.
Rationale 3: A decreased blood sugar indicates hypoglycemia, which has many causes, but is not related to hepatotoxicity.
Rationale 4: Impaired liver function would cause an increased or prolonged prothrombin time.
Global Rationale: Elevated liver function tests, which include the enzymes ALT and AST, are indicative of liver inflammation and/or impaired function of the liver. Elevated creatinine levels are indicative of impaired renal function. A decreased blood sugar indicates hypoglycemia, which has many causes, but is not related to hepatotoxicity. Impaired liver function would cause an increased or prolonged prothrombin time.
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